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Top stories from Vancouver.]Perspectives in Drug Discovery and Design. Balanced enzymatic activity is one of the keystones of physiology and pathophysiology. In organisms, the up- and downregulation of proteolytic enzymes reflects physiological adaptation as well as the presence or development of disease. Advances in molecular biology have revealed numerous aspects in the field of cysteine proteinase research. Several novel members of this growing family of proteinases, such as cathepsins H, S, Gay b;b Ladner O, have been found to participate in inflammatory and arthritic diseases.
Interestingly, the majority of the data addressing the involvement of cysteine proteinases in pathophysiological pathways are the result of intensive research on two diseases, periodontal disease and rheumatoid arthritis, which share distinct features of cysteine-proteinase-modulated inflammation and matrix degradation.
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Download preview PDF. Skip to main content. Advertisement Hide. Cysteine proteinases in arthritis and inflammation. This process is experimental and the keywords may be updated as the learning algorithm improves.
Rheumatoid arthritis progression mediated by activated synovial fibroblasts.
This is a preview of subscription content, log in to check access. Cazzulo, J. Google Scholar. Lemere, C.
Saito, K. Neumann E(1), Lefèvre S, Zimmermann B, Gay S, Müller-Ladner U. Author information: (1)Dept of Internal Medicine and Rheumatology. Jenna B. Ladner is on Facebook. Join Facebook to connect with Jenna B.
Ladner and others you may know. Facebook gives people the power to share. Relationship between cathepsin B and thrombin in rheumatoid arthritis.
J Rheumatol 31(7): – Muller-Ladner U, Kriegsmann J, Gay RE, Koopman WJ.
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Cysteine proteinases in arthritis and inflammation
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